Selank
Selank Peptide
Selank is a synthetic peptide with anxiolytic and nootropic properties, developed in Russia as a derivative of tuftsin. It has been studied for its ability to reduce anxiety without sedation and improve cognitive function.
Buy Selank at Peptide PalacePurity
99%+
Molecular Weight
751.87 g/mol
Administration
Intranasal spray
Storage
Store at 2-8°C
Mechanism of Action
Selank modulates the expression of BDNF, affects serotonin metabolism, and influences the balance of T-helper cell cytokines. It also stabilizes enkephalins in the blood, contributing to its anxiolytic effects without causing sedation.
Sequence:
Thr-Lys-Pro-Arg-Pro-Gly-Pro Chemical Structure
Research Areas
- Generalized anxiety
- Cognitive function
- Immune modulation
- Depression
- Stress adaptation
Potential Benefits
- Reduced anxiety without sedation
- Improved cognitive function
- Enhanced stress resilience
- Immune support
- Mood stabilization
Research Dosing Guidelines
For research purposes only. Not for human consumption.
Typical Dose
250-500 mcg
Frequency
2-3 times daily
Duration
14-21 days
Administration
Intranasal spray
Similar administration to Semax. Can be combined with Semax for synergistic effects.
Reconstitution Calculator
U-100 Insulin Syringe
10.0 units
2500 mcg/ml
0.100 ml
10.0 IU
20
For research and educational purposes only. Always follow proper reconstitution and sterile handling protocols.
Selank for Anxiety: Mechanism and Research Overview
Selank's anxiolytic mechanism is distinct from benzodiazepines and SSRIs, operating through enkephalin stabilization and serotonin modulation rather than direct GABA receptor binding.
Anxiolytic Comparison
| Factor | Selank | Benzodiazepines | SSRIs |
|---|---|---|---|
| Onset | Minutes (intranasal) | Minutes | Weeks |
| Sedation | None | Significant | Mild initially |
| Dependency risk | None observed | High | Moderate (withdrawal) |
| Cognitive effects | Enhancement | Impairment | Neutral to mild improvement |
| Duration | 3-5 hours | 4-8 hours | Continuous |
Selank's profile makes it particularly interesting for research into anxiolysis without cognitive impairment — a combination traditional medications struggle to achieve.
Potential Side Effects
- Fatigue (initial)
- Nasal irritation
- Generally very well tolerated
Storage Requirements
Store at 2-8°C.
Research References
- [1]Anxiolytic Effects of Selank (2004)Emerging Evidence Population: BALB/c mice in elevated plus maze
Selank produced significant anxiolytic effects comparable to benzodiazepines without sedation or motor impairment.
Limitations: Animal behavioral model; may not translate directly to human anxiety
- [2]Selank Enhances the Effect of Diazepam in Reducing Anxiety (2017)Emerging Evidence Population: Male Wistar rats
Co-administration of Selank with diazepam enhanced anxiolytic effects while reducing the sedative properties of the benzodiazepine.
Limitations: Drug interaction model; clinical relevance in humans uncertain
Frequently Asked Questions
What is Selank?
Selank is a synthetic peptide derived from tuftsin with notable anxiolytic and nootropic properties, developed in Russia. It has been studied for its unique ability to reduce anxiety without causing sedation while simultaneously improving cognitive function.
What are the potential research benefits of Selank?
Research indicates Selank may reduce anxiety without sedation, improve cognitive function, enhance stress resilience, and provide immune support. It works by modulating BDNF expression, serotonin metabolism, and stabilizing enkephalins in the blood.
How is Selank typically dosed in research?
Selank is typically administered at 250-500 mcg two to three times daily via intranasal spray. Research cycles generally last 14-21 days, and it can be combined with Semax for synergistic cognitive and anxiolytic effects.
What are the side effects of Selank?
Selank is generally very well tolerated in research settings. Minor side effects may include initial fatigue and nasal irritation from intranasal administration, both of which typically resolve quickly.
How should Selank be stored?
Selank should be stored at 2-8°C to maintain its stability and potency. Proper refrigeration is essential for preserving the peptide's biological activity throughout the research cycle.
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