Ipamorelin
Ipamorelin Acetate
Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist. It is known for producing a clean growth hormone release without significantly affecting cortisol or prolactin levels, making it one of the safest GH-releasing peptides.
Buy Ipamorelin at Peptide PalacePurity
99%+
Molecular Weight
711.85 g/mol
Administration
Subcutaneous injection
Storage
Store at -20°C
Mechanism of Action
Ipamorelin selectively binds to ghrelin receptors in the pituitary gland, triggering the release of growth hormone. Unlike other GHRPs, it does not significantly increase appetite, cortisol, acetylcholine, prolactin, or aldosterone.
Sequence:
Aib-His-D-2-Nal-D-Phe-Lys-NH2 Chemical Structure
Research Areas
- Growth hormone optimization
- Body composition
- Bone density
- Anti-aging
- Sleep improvement
Potential Benefits
- Clean GH release
- Minimal side effects
- Improved sleep
- Enhanced recovery
- Better body composition
Research Dosing Guidelines
For research purposes only. Not for human consumption.
Typical Dose
100-300 mcg
Frequency
2-3 times daily
Duration
8-12 weeks
Administration
Subcutaneous injection, preferably before bed and upon waking
Best results when combined with CJC-1295 (no DAC) for synergistic GH release.
Reconstitution Calculator
U-100 Insulin Syringe
4.0 units
2500 mcg/ml
0.040 ml
4.0 IU
50
For research and educational purposes only. Always follow proper reconstitution and sterile handling protocols.
Ipamorelin vs GHRP-6: Choosing a Growth Hormone Secretagogue
Ipamorelin and GHRP-6 both trigger growth hormone release through the ghrelin receptor, but they differ dramatically in selectivity and side-effect profiles.
Head-to-Head Comparison
| Factor | Ipamorelin | GHRP-6 |
|---|---|---|
| Selectivity | Highly selective GH release | Non-selective — raises cortisol, prolactin |
| Appetite effect | Minimal | Significant increase |
| GH pulse | Clean, moderate pulse | Stronger but "dirtier" pulse |
| Best paired with | CJC-1295 (no DAC) | CJC-1295 (no DAC) |
| Side effects | Mild headache, flushing | Hunger, water retention, cortisol spike |
| Best for | Anti-aging, sleep, lean body composition | Bulking, appetite stimulation, mass gain |
For most research goals, Ipamorelin is the preferred choice due to its clean GH release profile. GHRP-6 remains relevant when appetite stimulation is a desired outcome, such as in muscle-wasting or underweight research models.
Potential Side Effects
- Headache (mild)
- Dizziness
- Flushing
- Injection site reactions
Storage Requirements
Store at -20°C. Reconstituted solution at 2-8°C for up to 4 weeks.
Research References
- [1]Ipamorelin, a New Growth-Hormone-Releasing Peptide (1998)Emerging Evidence Population: Pentobarbital-anesthetized swine
Ipamorelin selectively stimulated growth hormone release without affecting cortisol, prolactin, or ACTH levels in swine.
Limitations: Animal model; anesthesia may affect hormonal responses
- [2]Ipamorelin Induces Longitudinal Bone Growth in Rats (1999)Emerging Evidence Population: Female rats treated for 15 days
Chronic ipamorelin treatment significantly increased longitudinal bone growth and body weight gain in rats.
Limitations: Single animal species; juvenile growth model only
Frequently Asked Questions
What is Ipamorelin?
Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist known for producing a clean growth hormone release. Unlike other GH-releasing peptides, it does not significantly affect cortisol or prolactin levels, making it one of the safest options in this class.
What are the potential research benefits of Ipamorelin?
Research indicates Ipamorelin may promote clean growth hormone release with minimal side effects, improve sleep quality, enhance recovery, and support better body composition. Its selective action on ghrelin receptors avoids the appetite-stimulating effects seen with other GHRPs.
How is Ipamorelin typically dosed in research?
Ipamorelin is typically administered at 100-300 mcg via subcutaneous injection, two to three times daily, preferably before bed and upon waking. Research cycles generally last 8-12 weeks, often in combination with CJC-1295 for synergistic effects.
What are the side effects of Ipamorelin?
Side effects of Ipamorelin are generally mild and may include headache, dizziness, flushing, and injection site reactions. It is considered one of the best-tolerated growth hormone secretagogues due to its selective receptor activity.
How should Ipamorelin be stored?
Ipamorelin should be stored at -20°C in lyophilized form. Once reconstituted, the solution should be kept at 2-8°C and can remain stable for up to four weeks.
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Safety & Reference
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